As Dengue Fever Sweeps India, a Slow Response Stirs Experts’ Fears
Enrico Fabian for The New York Times
NEW DELHI — An epidemic of dengue fever in India
is fostering a growing sense of alarm even as government officials here
have publicly refused to acknowledge the scope of a problem that
experts say is threatening hundreds of millions of people, not just in
India but around the world.
India has become the focal point for a mosquito-borne plague that is
sweeping the globe. Reported in just a handful of countries in the
1950s, dengue (pronounced DEN-gay) is now endemic in half the world’s
nations.
“The global dengue problem is far worse than most people know, and it
keeps getting worse,” said Dr. Raman Velayudhan, the World Health
Organization’s lead dengue coordinator.
The tropical disease, though life-threatening for a tiny fraction of
those infected, can be extremely painful. Growing numbers of Western
tourists are returning from warm-weather vacations with the disease,
which has reached the shores of the United States and Europe. Last
month, health officials in Miami announced a case of locally acquired
dengue infection.
Here in India’s capital, where areas of standing water contribute to the
epidemic’s growth, hospitals are overrun and feverish patients are
sharing beds and languishing in hallways. At Kalawati Saran Hospital, a
pediatric facility, a large crowd of relatives lay on mats and blankets
under the shade of a huge banyan tree outside the hospital entrance
recently.
Among them was Neelam, who said her two grandchildren were deathly ill
inside. Eight-year-old Sneha got the disease first, followed by Tanya,
7, she said. The girls’ parents treated them at home but then Sneha’s
temperature rose to 104 degrees, a rash spread across her legs and
shoulders, and her pain grew unbearable.
“Sneha has been given five liters of blood,” said Neelam, who has one name. “It is terrible.”
Officials say that 30,002 people in India had been sickened with dengue
fever through October, a 59 percent jump from the 18,860 recorded for
all of 2011. But the real number of Indians who get dengue fever
annually is in the millions, several experts said.
“I’d conservatively estimate that there are 37 million dengue infections
occurring every year in India, and maybe 227,500 hospitalizations,”
said Dr. Scott Halstead, a tropical disease expert focused on dengue
research.
A senior Indian government health official, who agreed to speak about
the matter only on the condition of anonymity, acknowledged that
official figures represent a mere sliver of dengue’s actual toll. The
government only counts cases of dengue that come from public hospitals
and that have been confirmed by laboratories, the official said. Such a
census, “which was deliberated at the highest levels,” is a small subset
that is nonetheless informative and comparable from one year to the
next, he said.
“There is no denying that the actual number of cases would be much, much
higher,” the official said. “Our interest has not been to arrive at an
exact figure.”
The problem with that policy, said Dr. Manish Kakkar, a specialist at
the Public Health Foundation of India, is that India’s “massive
underreporting of cases” has contributed to the disease’s spread.
Experts from around the world said that India’s failure to construct an
adequate dengue surveillance system has impeded awareness of the
illness’s vast reach, discouraged efforts to clean up the sources of the
disease and slowed the search for a vaccine.
“When you look at the number of reported cases India has, it’s a joke,”
said Dr. Harold S. Margolis, chief of the dengue branch at the Centers
for Disease Control and Prevention in Atlanta.
Neighboring Sri Lanka, for instance, reported nearly three times as many
dengue cases as India through August, according to the World Health
Organization, even though India’s population is 60 times larger.
Part of India’s problem is that some officials view reports of dengue
infections as politically damaging. In September, Mamata Banerjee, the
chief minister of West Bengal, dismissed reports of an increasing number
of dengue-related deaths, saying doctors were misdiagnosing. “So
everyone is earning a bad name,” she said at a news conference.
A central piece of evidence for those who contend that India suffers
hundreds of times more dengue cases than the government acknowledges is a
recent and as yet unpublished study
of dengue infections in West Bengal that found about the same presence
of dengue as in Thailand, where almost every child is infected by dengue
at least once before adulthood.
“I would say that anybody over the age of 20 in India has been infected
with dengue,” said Dr. Timothy Endy, chief of infectious disease at
Upstate Medical University in Syracuse.
For those who arrive in India as adults, “you have a reasonable
expectation of getting dengue after a few months,” said Dr. Joseph M.
Vinetz, a professor at the University of California at San Diego. “If
you stay for a longer period, it’s a certainty.”
The reason that such an extensive epidemic can hide in plain sight is
that as many as 80 percent of dengue infections cause only mild symptoms
of fatigue, said Anthony S. Fauci, director of the National Institute
of Allergy and Infectious Diseases. For many, the disease is experienced
as “maybe just a fever that someone shrugs off.”
But the remaining 20 percent may be affected by more serious flulike symptoms, with high fever, vomiting,
searing pain behind the eyes, skin rash, and muscle and joint aches
that can be so intense that the illness has been dubbed “breakbone
fever.”
The acute part of the illness generally passes within two weeks, but
symptoms of fatigue and depression can linger for months. In about 1
percent of cases, dengue advances to a life-threatening cascade of
immune responses known as hemorrhagic or shock dengue.
This potentially mortal condition generally happens only after a second
dengue infection. There are four strains of the dengue virus, and
infection with a second strain can fool the immune system, allowing the
virus to replicate. When the body finally realizes its mistake, it
floods the system with so many immune attackers that they are poisonous.
Such patients must be provided intravenous fluids and round-the-clock
care to avoid death.
Twenty years ago, just one of every 50 tourists who returned from the
tropics with fever was infected by dengue; now, it is one in six, said
Dr. Velayudhan, the W.H.O. official. The Portuguese archipelago of
Madeira is in the midst of an epidemic.
On Oct. 9, Puerto Rico’s Health Department declared a dengue epidemic
after at least six people died and nearly 5,000 people were sickened.
The great danger of having hundreds of millions of people in India with
undiagnosed and unacknowledged primary infections is that a sudden shift
in the circulating dengue strain could cause a widespread increase in
life-threatening illnesses.
“We have been fortunate so far,” said Dr. Kakkar of the Indian public
health group. “But if, God forbid, we come across that situation we
probably need far better health-care management and inpatient care
facilities.”
Trucks spewing pesticides
against mosquitoes are now a regular presence in New Delhi
neighborhoods, but rapid and disorderly urbanization — a hallmark of
India’s development — increases the risks of dengue proliferation, so
few believe the government here can do much to halt its spread.
The best hope for relief is a vaccine, but a recent trial of the most advanced vaccine candidate largely failed.
“I think we’re looking at 10 to 12 years before we see an effective
vaccine, and that’s if we’re lucky,” Dr. Halstead said. “In the
meantime, we’re in trouble.”
Labels: Disease, Environment, Health, India, Nature
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